eIF5A/eIF5A2 Polyclonal Antibody
Ucallm_WP16152-50
Price range: $268.00 through $328.00
Product details
Background:
Specifications
| Size | 50μL/100μL |
| Target | eIF5A/eIF5A2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 17kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA(peptide)1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human eIF5A/eIF5A2 |
| Specificity | This antibody detects endogenous levels of human eIF5A/eIF5A2 |
| Gene Name | EIF5A |
| Protein Name | eIF5A/eIF5A2 |
| Other Name | Eukaryotic translation initiation factor 5A-1; / eIF-5A-1; / eIF-5A1; / Eukaryotic initiation factor 5A isoform 1; / eIF-5A; / Rev-binding factor; / eIF-4D |
| Species | Human |
| Gene ID | 1984 |
| Uniprot | P63241;Q9GZV4 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Nucleus . Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side . Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions (PubMed:19379712, PubMed:27306458). Nuclear export of hypusinated protein is mediated by XPO4 (PubMed:10944119, PubMed:27306458). . |
| Tissue Expression | Expressed in umbilical vein endothelial cells and several cancer cell lines (at protein level). |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:The precise role of eIF-5A in protein biosynthesis is not known but it functions by promoting the formation of the first peptide bond.,PTM:eIF-5A seems to be the only eukaryotic protein to have an hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).,similarity:Belongs to the eIF-5A family.,subunit:Found in a complex with Ran and XPO4. The hypusine modification increases the interaction with XPO4.,tissue specificity:Expressed in umbilical vein endothelial cells and several cancer cell lines (at protein level)., |
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