Name: Elmo1 Polyclonal Antibody
SKU: WP15129
Price: 268 USD
Availability: InStock

Elmo1 Polyclonal Antibody

Ucallm_WP15129-50

Price range: $268.00 through $328.00

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100μl

50μl

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SKU: WP15129-100

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Product details

Background:

This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013],

Specifications

Size	50μL/100μL
Target	Elmo1
Reactivity	Human, Mouse
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	83kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human Elmo1. AA range:22-71
Specificity	Elmo1 Polyclonal Antibody detects endogenous levels of Elmo1 protein.
Gene Name	ELMO1
Protein Name	Engulfment and cell motility protein 1
Other Name	ELMO1; / KIAA0281; / Engulfment and cell motility protein 1; / Protein ced-12 homolog
Species	Human
Gene ID	9844
Uniprot	Q92556,
Species.1	Mouse
Gene ID.1	140580
Uniprot.1	Q8BPU7
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cytoplasm. Cell membrane. Translocation to plasma membrane seems to be mediated by DOCK1 and CRK.
Tissue Expression	Widely expressed, with a higher expression in the spleen and placenta.
Signaling_pathway	Organismal Systems >> Immune system >> Chemokine signaling pathway
Research Areas	>>Chemokine signaling pathway; / >>Bacterial invasion of epithelial cells; / >>Shigellosis; / >>Salmonella infection; / >>Yersinia infection
Function	Function:Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.,PTM:Phosphorylated by HCK.,similarity:Contains 1 ELMO domain.,similarity:Contains 1 PH domain.,subcellular location:Translocation to plasma membrane seems to be mediated by DOCK1 and CRK.,subunit:Interacts with BAI1 (By similarity). Interacts directly with the SH3-domain of DOCK1 via its SH3-binding site. Part of a complex with DOCK1 and RAC1. Part of a complex with DOCK1 and CRK isoform CRK-II. Interacts with PLEKHG6.,tissue specificity:Widely expressed, with a higher expression in the spleen and placenta.,

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Elmo1 Polyclonal Antibody

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Elmo1 Polyclonal Antibody

Product details

Specifications

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