Name: Endo180 Polyclonal Antibody
SKU: WP12182
Price: 268 USD
Availability: InStock

Endo180 Polyclonal Antibody

Ucallm_WP12182-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WP12182-100

Enter the quantity you would like, or drag the panel to find the quantity and price that best for you

Bulk Quote Authorize OEM & ODM

Product details

Background:

mannose receptor C type 2(MRC2) Homo sapiens This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012],

Specifications

Size	50μL/100μL
Target	Endo180
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	167kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human MRC2. AA range:121-170
Specificity	Endo180 Polyclonal Antibody detects endogenous levels of Endo180 protein.
Gene Name	MRC2
Protein Name	C-type mannose receptor 2
Other Name	MRC2; / CLEC13E; / ENDO180; / KIAA0709; / UPARAP; / C-type mannose receptor 2; / C-type lectin domain family 13 member E; / Endocytic receptor 180; / Macrophage mannose receptor 2; / Urokinase-type plasminogen activator receptor-associated protein; / UPAR-asso
Species	Human
Gene ID	9902
Uniprot	Q9UBG0,
Species.1	Mouse
Gene ID.1	17534
Uniprot.1	Q64449,
Species.2	Rat
Gene ID.2	498011
Uniprot.2	Q4TU93
Cellular Localization	Membrane; Single-pass type I membrane protein.
Tissue Expression	Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney.
Signaling_pathway	Cellular Processes >> Transport and catabolism >> Phagosome
Research Areas	>>Phagosome; / >>Tuberculosis
Function	Domain:C-type lectin domains 3 to 8 are not required for calcium-dependent binding of mannose, fucose and N-acetylglucosamine. C-type lectin domain 2 is responsible for sugar-binding in a calcium-dependent manner.,Domain:Fibronectin type-II domain mediates collagen-binding.,Domain:Ricin B-type lectin domain contacts with the second C-type lectin domain.,Function:May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix co-operating with the matrix metalloproteinases (MMPs).,online information:Endo180,PTM:N-glycosylated.,PTM:Phosphorylated.,similarity:Contains 1 fibronectin type-II domain.,similarity:Contains 1 ricin B-type lectin domain.,similarity:Contains 8 C-type lectin domains.,subunit:Interacts with C-terminal region of type I collagen/COL1A1 (By similarity). Interacts directly with PLAUR/UPAR and PLAU/pro-UPA to form a tri-molecular complex. Interacts with collagen V.,tissue specificity:Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney.,