SKU: WP15887 Categories: ,

Eotaxin-2 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP15887-100
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Product details

Background:

This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetEotaxin-2
ReactivityHuman, Mouse
ApplicationsIHC, IF, ELISA
MW(Calculated)
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:50-200; ELISA 1:10000-20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthetic peptide from human protein at AA range: 61-110
SpecificityThe antibody detects endogenous Eotaxin-2
Gene NameCCL24 MPIF2 SCYA24
Protein NameC-C motif chemokine 24 (CK-beta-6) (Eosinophil chemotactic protein 2) (Eotaxin-2) (Myeloid progenitor inhibitory factor 2) (MPIF-2) (Small-inducible cytokine A24)
Other NameCCL24; / MPIF2; / SCYA24; / C-C motif chemokine 24; / CK-beta-6; / Eosinophil chemotactic protein 2; / Eotaxin-2; / Myeloid progenitor inhibitory factor 2; / MPIF-2; / Small-inducible cytokine A24
SpeciesHuman
Gene ID6369
UniprotO00175,
Species.1Mouse
Gene ID.156221
Uniprot.1Q9JKC0
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationSecreted .
Tissue ExpressionActivated monocytes and activated T lymphocytes.
Signaling_pathwayOrganismal Systems >> Immune system >> Chemokine signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction;Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor
Research Areas>>Cytokine-cytokine receptor interaction; / >>Viral protein interaction with cytokine and cytokine receptor; / >>Chemokine signaling pathway
FunctionFunction:Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. Binds to CCR3.,online information:CCL24 entry,PTM:N-glycosylated.,similarity:Belongs to the intercrine beta (chemokine CC) family.,tissue specificity:Activated monocytes and activated T lymphocytes.,
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