Ep-CAM [ABT-EPCAM] mouse mAb
Ucallm_WM1523-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008],
Specifications
| Size | 50μL/100μL |
| Target | CD326/EPCAM |
| Reactivity | Human |
| Applications | IHC, WB, IF, ELISA |
| MW(Calculated) | 35kD |
| MW(Observed) | 42kD |
| Host Species | Mouse |
| Isotype | IgG2b,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-500; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMM-EPCAM |
| Immunogen | Synthesized peptide derived from human Ep-CAM AA range: 100-200 |
| Specificity | This antibody detects endogenous levels of Ep-CAM protein. |
| Gene Name | EPCAM GA733-2 M1S2 M4S1 MIC18 TACSTD1 TROP1 |
| Protein Name | Epithelial cell adhesion molecule |
| Other Name | EPCAM; / GA733-2; / M1S2; / M4S1; / MIC18; / TACSTD1; / TROP1; / Epithelial cell adhesion molecule; / Ep-CAM; / Adenocarcinoma-associated antigen; / Cell surface glycoprotein Trop-1; / Epithelial cell surface antigen; / Epithelial glycoprotein; / EGP; / Epithelial gly |
| Species | Human |
| Gene ID | 4072 |
| Uniprot | P16422 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membranous |
| Tissue Expression | Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma. |
| Signaling_pathway | |
| Research Areas | |
| Function |
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