Price range: $268.00 through $328.00
Background:
function:Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis., PTM:Phosphorylated on tyrosine residues by EGFR., similarity:Contains 1 EF-hand domain., similarity:Contains 3 EH domains., subcellular location:Localized to plasma membrane coated pits., subunit:Interacts with EPS15, AGFG1/HRB and AGFG2/HRBL. Associates with the clathrin-associated adapter protein complex 2 (AP-2).,
| Size | 50μL/100μL |
| Target | EP15R |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 95kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 350-430 |
| Specificity | EP15R Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | EPS15L1 EPS15R |
| Protein Name | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) |
| Other Name | |
| Species | Human |
| Gene ID | 58513 |
| Uniprot | Q9UBC2, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q60902 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Peripheral membrane protein . Nucleus . Membrane, coated pit . Localized to plasma membrane coated pits. . |
| Tissue Expression | Brain,Epithelium,Fetal brain,T-cell,Uterus, |
| Signaling_pathway | |
| Research Areas | >>Endocytosis |
| Function | Function:Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis.,PTM:Phosphorylated on tyrosine residues by EGFR.,similarity:Contains 1 EF-hand domain.,similarity:Contains 3 EH domains.,subcellular location:Localized to plasma membrane coated pits.,subunit:Interacts with EPS15, AGFG1/HRB and AGFG2/HRBL. Associates with the clathrin-associated adapter protein complex 2 (AP-2)., |
