EpCAM mouse mAb
Ucallm_WM0582-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008],
Specifications
| Size | 50μL/100μL |
| Target | CD326/EPCAM |
| Reactivity | Human |
| Applications | WB, IP |
| MW(Calculated) | |
| MW(Observed) | 39kD |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:1000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 16B5 |
| Immunogen | Purified recombinant EpCAM protein fragments expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of EpCAM and does not cross-react with related proteins. |
| Gene Name | EPCAM GA733-2 M1S2 M4S1 MIC18 TACSTD1 TROP1 |
| Protein Name | |
| Other Name | 17 1A; / 323/A3; / Adenocarcinoma associated antigen; / Adenocarcinoma-associated antigen; / Antigen identified by monoclonal antibody AUA1; / AUA1; / CD326; / CD326 antigen; / Cell surface glycoprotein Trop 1; / Cell surface glycoprotein Trop 2; / Cell surface glycoprotein Trop-1; / CO 17A; / CO17 1A; / CO17A; / DIAR5; / EGP 2; / EGP; / EGP2; / EGP314; / EGP40; / Ep CAM; / Ep-CAM; / EPCAM; / EPCAM_HUMAN; / Epithelial cell adhesion molecule; / Epithelial Cell Adhesion Molecule Intracellular Domain; / EpCAM-ICD; / Epithelial cell surface antigen; / Epithelial cellular adhesion molecule; / Epithelial glycoprotein 1; / Epithelial glycoprotein 314; / Epithelial glycoprotein; / ESA; / GA733 1; / GA733 2; / GA733-2; / gastrointestinal tumor-associated antigen 2, 35-KD glycoprotein; / hEGP 2; / hEGP314; / HNPCC8; / Human epithelial glycoprotein 2; / KS 1/4 antigen; / KS1/4; / KSA; / Lymphocyte antigen 74; / M1S 1; / M1S2; / M4S1; / Major gastrointestinal tumor associated protein GA733 2; / Major gastrointestinal tumor-associated protein GA733-2; / Membrane component chromosome 4 surface marker; / 35kD glycoprotein; / Membrane component, chromosome 4, surface marker 1; / Membrane component, chromosome 4, surface marker; / MIC18; / MK 1; / TACD1; / TACSTD1; / TROP1; / Tumor associated calcium signal transducer 1; / Tumor associated calcium signal transducer 2 precursor; / Tumor-associated calcium signal transducer 1. |
| Species | Human |
| Gene ID | 4072 |
| Uniprot | P16422, |
| Species.1 | Mouse |
| Gene ID.1 | 17075 |
| Uniprot.1 | Q99JW5 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Lateral cell membrane; Single-pass type I membrane protein . Cell junction, tight junction . Colocalizes with CLDN7 at the lateral cell membrane and tight junction. . |
| Tissue Expression | Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma. |
| Signaling_pathway | |
| Research Areas | |
| Function |
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