Price range: $268.00 through $328.00
Background:
Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells (Aasheim et al., 2005 [PubMed 15777695]). See MIM 179610 for additional background on Eph receptors and ephrins.[supplied by OMIM, Mar 2008],
| Size | 50μL/100μL |
| Target | EphA10 |
| Reactivity | Human |
| Applications | WB, ELISA |
| MW(Calculated) | 110kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 11F1 |
| Immunogen | Purified recombinant fragment of human EphA10 expressed in E. Coli. |
| Specificity | EphA10 Monoclonal Antibody detects endogenous levels of EphA10 protein. |
| Gene Name | EPHA10 |
| Protein Name | Ephrin type-A receptor 10 |
| Other Name | EPHA10; / Ephrin type-A receptor 10 |
| Species | Human |
| Gene ID | 284656 |
| Uniprot | Q5JZY3 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | [Isoform 1]: Cell membrane; Single-pass type I membrane protein .; [Isoform 3]: Cell membrane; Single-pass type I membrane protein .; [Isoform 2]: Secreted . |
| Tissue Expression | Mainly expressed in testis. |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,Domain:The protein kinase domain is predicted to be catalytically inactive.,Function:Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,tissue specificity:Mainly expressed in testis., |
