Name: Ephrin-A1 Polyclonal Antibody
SKU: WP12214
Price: 268 USD
Availability: InStock

Ephrin-A1 Polyclonal Antibody

Ucallm_WP12214-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP12214-100

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Product details

Background:

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	Ephrin-A1
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	24kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human EFNA1. AA range:66-115
Specificity	Ephrin-A1 Polyclonal Antibody detects endogenous levels of Ephrin-A1 protein.
Gene Name	EFNA1 EPLG1 LERK1 TNFAIP4
Protein Name	Ephrin-A1
Other Name	EFNA1; / EPLG1; / LERK1; / TNFAIP4; / Ephrin-A1; / EPH-related receptor tyrosine kinase ligand 1; / LERK-1; / Immediate early response protein B61; / Tumor necrosis factor alpha-induced protein 4; / TNF alpha-induced protein 4; / [Cleaved into: Ephrin-A1, secreted form]
Species	Human
Gene ID	1942
Uniprot	P20827,
Species.1	Mouse
Gene ID.1	13636
Uniprot.1	P52793,
Species.2	Rat
Gene ID.2	94268
Uniprot.2	P97553
Cellular Localization	Cell membrane; Lipid-anchor, GPI-anchor .; [Ephrin-A1, secreted form]: Secreted .
Tissue Expression	Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level).
Signaling_pathway	Human Diseases >> Cancer: overview >> MicroRNAs in cancer;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> Ras signaling pathway;Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
Research Areas	>>MAPK signaling pathway; / >>Ras signaling pathway; / >>Rap1 signaling pathway; / >>PI3K-Akt signaling pathway; / >>Axon guidance; / >>MicroRNAs in cancer
Function	induction:By TNF-alpha and interleukin-1 beta.,similarity:Belongs to the ephrin family.,subunit:Binds to the receptor tyrosine kinases EPHA2, EPHA4, EPHA5, EPHA6 and EPHA7. Also binds with low affinity to EPHA1.,