EPS8 Polyclonal Antibody
Ucallm_WP0536-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | EPS8 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 90kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 130-210 |
| Specificity | EPS8 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | EPS8 |
| Protein Name | Epidermal growth factor receptor kinase substrate 8 |
| Other Name | |
| Species | Human |
| Gene ID | 2059 |
| Uniprot | Q12929, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q08509 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm, cell cortex . Cell projection, ruffle membrane . Cell projection, growth cone . Cell projection, stereocilium . Cell junction, synapse, synaptosome . Localizes at the tips of the stereocilia of the inner and outer hair cells (By similarity). Localizes to the midzone of dividing cells. . |
| Tissue Expression | Expressed in all tissues analyzed, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in all epithelial and fibroblastic lines examined and in some, but not all, hematopoietic cells. |
| Signaling_pathway | |
| Research Areas | |
| Function | Domain:The SH3 domain mediates interaction with SHB.,Function:Upon binding to EGF receptor enhances EGF-dependent mitogenic signals. Can bind multiple cellular targets.,PTM:Phosphorylated by several receptor tyrosine kinases.,similarity:Belongs to the EPS8 family.,similarity:Contains 1 PH domain.,similarity:Contains 1 SH3 domain.,subunit:Homodimer (By similarity). Interacts with BAIAP2. Interacts with SHB.,tissue specificity:Expressed in all tissues analyzed, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in all epithelial and fibroblastic lines examined and in some, but not all, hematopoietic cells., |
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