Product details
Background:
ESRP1 rabbit pAb
Ucallm_WP6329-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | ESRP1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 75kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ESRP1 |
| Specificity | This antibody detects endogenous levels of ESRP1 at Human, Mouse,Rat |
| Gene Name | ESRP1 RBM35A |
| Protein Name | Epithelial splicing regulatory protein 1 (RNA-binding motif protein 35A) (RNA-binding protein 35A) |
| Other Name | |
| Species | Human |
| Gene ID | 54845 |
| Uniprot | Q6NXG1, |
| Species.1 | Mouse |
| Gene ID.1 | 207920 |
| Uniprot.1 | Q3US41, |
| Species.2 | Rat |
| Gene ID.2 | 500409 |
| Uniprot.2 | B2RYD2 |
| Cellular Localization | Nucleus . |
| Tissue Expression | Epithelial cell-specific. |
| Signaling_pathway | |
| Research Areas | |
| Function | mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 . Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium (By similarity). |
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