Name: Factor XIIIa [ABT170] mouse mAb
SKU: WM1420
Price: 268 USD
Availability: InStock

Product details

Background:
Factor XIIIa is found in plasma β Globulin. It is expressed in monocytes, macrophages, megakaryocytes, dendritic reticular cells in reactive lymph nodes, dermal dendritic cells, fibroblast like stromal cells and Kupffer cells in liver. It can be used as a marker of dermal dendritic cells. The tumors showed positive expression in dermal fibroma, atypical xanthoma, malignant fibrous histiocytoma, fibrous histiocytoma, some sarcomas, granulosa cell tumor and neurofibroma.

Specifications

Size	50μL/100μL
Target	Factor XIIIa
Reactivity	Human, Mouse, Rat
Applications	IHC, WB, IF, ELISA
MW(Calculated)	76kD,83kD
MW(Observed)	83kD
Host Species	Mouse
Isotype	IgG1,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RMM170
Immunogen	Synthesized peptide derived from human Factor XIIIa AA range: 400-500
Specificity	The antibody can specifically recognize human Factor XIIIa protein. In western blotting of A431 cell lysates, there shows a 100 kDa band detected by the antibody.
Gene Name	F13A1 F13A
Protein Name	Factor XIIIa
Other Name	bA525O21.1; / coagulation factor XIII, A1 polypeptide; / Coagulation factor XIII A chain; / Coagulation factor XIII A1 polypeptide; / Coagulation factor XIII A1 subunit; / Coagulation factor XIII, A polypeptide; / Coagulation factor XIIIa; / F13A; / F13A_HUMAN; / F13a1; / Factor XIIIA; / Fibrin stabilizing factor, A subunit; / Fibrinoligase; / FSF, A subunit; / Protein glutamine gamma glutamyltransferase A chain; / Protein-glutamine gamma-glutamyltransferase A chain; / TGase; / Transglutaminase A chain; / Transglutaminase, plasma; / Transglutaminase. plasma
Species	Human
Gene ID	2162
Uniprot	P00488
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cytoplasmic
Tissue Expression	Cytoplasmic
Signaling_pathway	Organismal Systems >> Immune system >> Complement and coagulation cascades
Research Areas	>>Complement and coagulation cascades; / >>Coronavirus disease - COVID-19
Function	Catalytic activity:Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3).,cofactor:Binds 1 calcium ion per subunit.,Disease:Defects in F13A1 are the cause of F13A deficiency [MIM:134570]. F13A deficiency is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women. In addition to the common presentation such as subcutaneous and intramuscular haematomas, severe bleeding such as intracranial hemorrhages may occur.,Function:Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.,online information:Factor XIII entry,online information:The Singapore human mutation and polymorphism database,polymorphism:There are four main allelic forms of this protein; F13A1A, F13A1B, F13A2A and F13A2B. In addition two other intermediate forms (F13A(2)A and F13A(2)B) seem to exist. The sequence shown is that of F13A*(2)B.,PTM:The activation peptide is released by thrombin.,similarity:Belongs to the transglutaminase superfamily. Transglutaminase family.,subcellular location:Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma.,subunit:Tetramer of two A chains and two B chains.,