Product details
Background:
FAM175B rabbit pAb
Ucallm_WP8745-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | ABRAXAS2 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 46kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human FAM175B |
| Specificity | This antibody detects endogenous levels of FAM175B at Human, Mouse |
| Gene Name | FAM175B ABRO1 KIAA0157 |
| Protein Name | BRISC complex subunit Abro1 (Abraxas brother protein 1) (Protein FAM175B) |
| Other Name | |
| Species | Human |
| Gene ID | 23172 |
| Uniprot | Q15018, |
| Species.1 | Mouse |
| Gene ID.1 | 109359 |
| Uniprot.1 | Q3TCJ1 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton . A minor proportion is detected in the nucleus (PubMed:21282113, PubMed:22974638). Translocates into the nucleus in response to DNA damage (PubMed:25283148). Directly binds to microtubules and is detected at the minus end of K-fibers (PubMed:26195665). Co-localizes with NUMA1 at mitotic spindle poles (PubMed:26195665). . |
| Tissue Expression | Detected in heart muscle (at protein level). Detected in heart and muscle, and at much lower levels in brain (PubMed:21195082). |
| Signaling_pathway | |
| Research Areas | |
| Function | Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates . May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm . Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 . Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression . Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination . Required for normal induction of p53/TP53 in response to DNA damage . Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage . |
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