Product details
Background:
FANCI rabbit pAb
Ucallm_WP7153-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | FANCI |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 146kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human FANCI |
| Specificity | This antibody detects endogenous levels of FANCI at Human, Mouse |
| Gene Name | FANCI KIAA1794 |
| Protein Name | Fanconi anemia group I protein (Protein FACI) |
| Other Name | |
| Species | Human |
| Gene ID | 55215 |
| Uniprot | Q9NVI1, |
| Species.1 | Mouse |
| Gene ID.1 | 208836 |
| Uniprot.1 | Q8K368 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Cytoplasm . Observed in spots localized in pairs on the sister chromatids of mitotic chromosome arms and not centromeres, one on each chromatids. These foci coincide with common fragile sites. They are frequently interlinked through BLM-associated ultra-fine DNA bridges. |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. Required for maintenance of chromosomal stability. Specifically binds branched DNA: binds both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). Participates in S phase and G2 phase checkpoint activation upon DNA damage. |
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