Price range: $268.00 through $328.00
Background:
This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | FDFT |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 46kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human FDFT AA range: 11-61 |
| Specificity | This antibody detects endogenous levels of FDFT at Human/Mouse/Rat |
| Gene Name | FDFT1 |
| Protein Name | FDFT |
| Other Name | |
| Species | Human |
| Gene ID | 2222 |
| Uniprot | P37268, |
| Species.1 | Mouse |
| Gene ID.1 | 14137 |
| Uniprot.1 | P53798, |
| Species.2 | Rat |
| Gene ID.2 | 29580 |
| Uniprot.2 | Q02769 |
| Cellular Localization | Endoplasmic reticulum membrane; Multi-pass membrane protein . |
| Tissue Expression | Widely expressed. |
| Signaling_pathway | |
| Research Areas | >>Steroid biosynthesis; / >>Metabolic pathways |
| Function | Catalytic activity:2 farnesyl diphosphate = diphosphate + presqualene diphosphate.,Catalytic activity:Presqualene diphosphate + NAD(P)H = squalene + diphosphate + NAD(P)(+).,cofactor:Magnesium.,pathway:Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl-PP: step 1/3.,similarity:Belongs to the phytoene/squalene synthetase family.,subunit:Monomer., |
