Name: Ferritin heavy chain Polyclonal Antibody
SKU: WP12292
Price: 268 USD
Availability: InStock

Ferritin heavy chain Polyclonal Antibody

Ucallm_WP12292-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP12292-100

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Product details

Background:

This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	Ferritin heavy chain
Reactivity	Human, Mouse, Rat
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	21kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from the Internal region of human Ferritin heavy chain. AA range 120-170
Specificity	Ferritin heavy chain Polyclonal Antibody detects endogenous levels of Ferritin heavy chain protein.
Gene Name	FTH1
Protein Name	Ferritin heavy chain
Other Name	FTH1; / FTH; / FTHL6; / OK/SW-cl.84; / PIG15; / Ferritin heavy chain; / Ferritin H subunit; / Cell proliferation-inducing gene 15 protein
Species	Human
Gene ID	2495
Uniprot	P02794,
Species.1	Mouse
Gene ID.1	14319
Uniprot.1	P09528,
Species.2	Rat
Gene ID.2	25319
Uniprot.2	P19132
Cellular Localization	cell,nucleus,cytoplasm,mitochondrion,cytosol,intracellular ferritin complex,integral component of membrane,autolysosome,extracellular exosome,
Tissue Expression	Expressed in the liver.
Signaling_pathway	Cellular Processes >> Cell growth and death >> Ferroptosis;Cellular Processes >> Cell growth and death >> Necroptosis
Research Areas	>>Ferroptosis; / >>Necroptosis; / >>Mineral absorption
Function	Catalytic activity:4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O.,Function:Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis.,Function:Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.,miscellaneous:In human liver the heavy chain is the major chain.,online information:Ferritin entry,similarity:Belongs to the ferritin family.,similarity:Contains 1 ferritin-like diiron domain.,subunit:Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.,