Price range: $268.00 through $328.00
Background:
function:May be involved in brain development during embryogenesis., miscellaneous:Contrarily to other members of the family that can bind several FGF receptors FGF19 is specific for FGFR4., similarity:Belongs to the heparin-binding growth factors family., tissue specificity:Expressed in fetal brain, cartilage, retina, and adult gall bladder.,
| Size | 50μL/100μL |
| Target | FGF19 |
| Reactivity | Human, Pig |
| Applications | WB, ELISA |
| MW(Calculated) | 24kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:1000-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human FGF-19 |
| Specificity | This antibody detects endogenous levels of Human FGF-19 |
| Gene Name | FGF19 UNQ334/PRO533 |
| Protein Name | FGF-19 |
| Other Name | Fibroblast growth factor 19; / FGF-19 |
| Species | Human |
| Gene ID | 9965 |
| Uniprot | O95750 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted. |
| Tissue Expression | Expressed in fetal brain, cartilage, retina, and adult gall bladder. |
| Signaling_pathway | Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Gastric cancer;Human Diseases >> Cancer: specific types >> Melanoma;Human Diseases >> Cancer: specific types >> Breast cancer;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> Ras signaling pathway;Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway;Environmental Information Processing >> Signal transduction >> Calcium signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway |
| Research Areas | >>MAPK signaling pathway; / >>Ras signaling pathway; / >>Rap1 signaling pathway; / >>Calcium signaling pathway; / >>PI3K-Akt signaling pathway; / >>Regulation of actin cytoskeleton; / >>Pathways in cancer; / >>Melanoma; / >>Breast cancer; / >>Gastric cancer |
| Function | ameboidal cell migration, neural crest cell migration, cell motion, heart development, negative regulation of biosynthetic process, positive regulation of signal transduction, regulation of cellular ketone metabolic process,regulation of protein kinase cascade, positive regulation of cell communication, positive regulation of protein kinase cascade, regulation of glucose transport, positive regulation of glucose transport, negative regulation of steroid biosynthetic process, mesenchymal cell development, neural crest cell development, neural crest cell differentiation,cell migration, regulation of lipid metabolic process, regulation of steroid metabolic process, negative regulation of cellular biosynthetic process, regulation of MAPKKK cascade, positive regulation of MAPKKK cascade, negative regulation of lipid metabolic process, negative regulation of steroid metabolic process, regulation of glucose import,positive regulation of glucose import, regulation of JNK cascade, positive regulation of JNK cascade, regulation of lipid biosynthetic process, positive regulation of response to stimulus, mesenchymal cell differentiation, cell motility,regulation of steroid biosynthetic process, positive regulation of transport, negative regulation of lipid biosynthetic process, localization of cell, mesenchyme development, regulation of stress-activated protein kinase signaling pathway, positive regulation of stress-activated protein kinase signaling pathway, regulation of ERK1 and ERK2 cascade, positive regulation of ERK1 and ERK2 cascade, regulation of cellular response to stress, |
