U-Blot® Flotillin-2 Rabbit mAb
Ucallm_WR5021-50
Price range: $268.00 through $328.00
Product details
Background:Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in neuronal signaling. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | Flotillin-2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IF, IP, ELISA |
| MW(Calculated) | 47kD |
| MW(Observed) | 47kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1253R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | FLOT2 ESA1 M17S1 |
| Protein Name | Flotillin-2 |
| Other Name | FLOT2; / ESA1; / M17S1; / Flotillin-2; / Epidermal surface antigen; / ESA; / Membrane component chromosome 17 surface marker 1 |
| Species | Human |
| Gene ID | 2319 |
| Uniprot | Q14254, |
| Species.1 | Mouse |
| Gene ID.1 | 14252 |
| Uniprot.1 | Q60634, |
| Species.2 | Rat |
| Gene ID.2 | 83764 |
| Uniprot.2 | Q9Z2S9 |
| Cellular Localization | Cell membrane; Peripheral membrane protein . Membrane, caveola; Peripheral membrane protein . Endosome . Membrane; Lipid-anchor . Membrane-associated protein of caveolae. |
| Tissue Expression | In skin, expressed in epidermis and epidermal appendages but not in dermis. Expressed in all layers of the epidermis except the basal layer. In hair follicles, expressed in the suprabasal layer but not the basal layer. Also expressed in melanoma and carcinoma cell lines, fibroblasts and foreskin melanocytes. |
| Signaling_pathway | Organismal Systems >> Endocrine system >> Insulin signaling pathway |
| Research Areas | >>Insulin signaling pathway |
| Function | Function:May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.,similarity:Belongs to the band 7/mec-2 family. Flotillin subfamily.,subcellular location:Membrane-associated protein of caveolae.,subunit:Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2.,tissue specificity:In skin, expressed in epidermis and epidermal appendages but not in dermis. Expressed in all layers of the epidermis except the basal layer. In hair follicles, expressed in the suprabasal layer but not the basal layer. Also expressed in melanoma and carcinoma cell lines, fibroblasts and foreskin melanocytes., |
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