Flt3-L Polyclonal Antibody
Ucallm_WP12322-50
Price range: $268.00 through $328.00
Product details
Background:
Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011],
Specifications
| Size | 50μL/100μL |
| Target | Flt3-L |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 26kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Flt3 ligand. AA range:171-220 |
| Specificity | Flt3-L Polyclonal Antibody detects endogenous levels of Flt3-L protein. |
| Gene Name | FLT3LG |
| Protein Name | Fms-related tyrosine kinase 3 ligand |
| Other Name | FLT3LG; / Fms-related tyrosine kinase 3 ligand; / Flt3 ligand; / Flt3L; / SL cytokine |
| Species | Human |
| Gene ID | 2323 |
| Uniprot | P49771, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P49772 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted. |
| Tissue Expression | Brain,Spleen, |
| Signaling_pathway | Organismal Systems >> Immune system >> Hematopoietic cell lineage;Human Diseases >> Cancer: overview >> Pathways in cancer;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> Ras signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway |
| Research Areas | >>MAPK signaling pathway; / >>Ras signaling pathway; / >>PI3K-Akt signaling pathway; / >>Hematopoietic cell lineage; / >>Pathways in cancer |
| Function | Function:Stimulates the proliferation of early hematopoietic cells. Synergizes well with a number of other colony stimulating factors and interleukins.,subunit:Homodimer (isoform 2)., |
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