Name: FOG-2 Polyclonal Antibody
SKU: WP15715
Price: 268 USD
Availability: InStock

Product details

Background:

zinc finger protein, FOG family member 2(ZFPM2) Homo sapiens The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	FOG-2
Reactivity	Human, Mouse
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	128kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC: 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from the Internal region of human ZFPM2. AA range:921-970
Specificity	FOG-2 Polyclonal Antibody detects endogenous levels of FOG-2 protein.
Gene Name	ZFPM2
Protein Name	Zinc finger protein ZFPM2
Other Name	ZFPM2; / FOG2; / ZNF89B; / Zinc finger protein ZFPM2; / Friend of GATA protein 2; / FOG-2; / Friend of GATA 2; / hFOG-2; / Zinc finger protein 89B; / Zinc finger protein multitype 2
Species	Human
Gene ID	23414
Uniprot	Q8WW38,
Species.1	Mouse
Gene ID.1	22762
Uniprot.1	Q8CCH7
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Nucleus .
Tissue Expression	Widely expressed at low level.
Signaling_pathway	Human Diseases >> Cancer: overview >> MicroRNAs in cancer
Research Areas	>>MicroRNAs in cancer
Function	Disease:Defects in ZFPM2 are the cause of diaphragmatic hernia 3 (DIH3) [MIM:610187]; a form of congenital diaphragmatic hernia (CDH). CDH refers to a group of congenital defects in the structural integrity of the diaphragm associated with often lethal pulmonary hypoplasia and pulmonary hypertension.,Disease:Defects in ZFPM2 may be a cause of tetralogy of Fallot (TOF) [MIM:187500]. TOF is a congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. This condition results in a blue baby at birth due to inadequate oxygenation. Surgical correction is emergent.,Domain:The CCHC-type zinc fingers 1, 5, 6 and 8 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC-type zinc finger is essential for the interaction with GATA-type zinc fingers.,Function:Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY.,similarity:Belongs to the FOG (Friend of GATA) family.,similarity:Contains 3 C2H2-type zinc fingers.,similarity:Contains 5 C2HC-type zinc fingers.,subunit:Interacts with the N-terminal zinc-finger of GATA4, GATA5 and probably GATA6. Interacts with retinoid nuclear receptor RXRA when ligand bound (By similarity). Interacts with corepressor CTBP2; this interaction is however not essential for corepressor activity. Able to bind GATA1 in vitro.,tissue specificity:Widely expressed at low level.,

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FOG-2 Polyclonal Antibody

Product details

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FOG-2 Polyclonal Antibody

Product details

Specifications

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