Name: U-Blot® FPGS Rabbit mAb
SKU: WR4773
Price: 268 USD
Availability: InStock

U-Blot® FPGS Rabbit mAb

Western Blot analysis using Jurkat lysates,primary antibody was diluted at 1:1000, 4°over night, Dylight 800 secondary antibody(WS0446)was diluted at 1:10000, 37° 1hour.

WR4773 Western Blot analysis using Jurkat lysates,primary antibody was diluted at 1:1000, 4°over night, Dylight 800 secondary antibody(WS0446)was diluted at 1:10000, 37° 1hour.

Price range: $268.00 through $328.00

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SKU: WR4773-50

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Product details

Background:This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]

Specifications

Target	FPGS
Reactivity	Human, Mouse, Rat
Applications	WB, FC
MW(Calculated)	65kD
MW(Observed)	65kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	WB 1:1000-1:5000; FC 1:100-1:500;
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	PT1133R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Sequence
Specificity	Endogenous
Gene Name	FPGS
Protein Name	Folylpolyglutamate synthase, mitochondrial (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase) (FPGS) (Tetrahydrofolylpolyglutamate synthase) (Tetrahydrofolate synthase)
Other Name
Species	Human
Gene ID-1	2356
Uniprot	Q05932,
Species.1	Mouse
Gene ID-2	14287
Uniprot.1	P48760
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Background	This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]
Cellular Localization	SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion inner membrane {ECO:0000269\|PubMed:16169100}. Mitochondrion matrix {ECO:0000269\|PubMed:16169100, ECO:0000269\|PubMed:8408020, ECO:0000269\|PubMed:8662720}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269\|PubMed:8662720}.
Tissue Expression
Signaling_pathway
Research Areas
Function	FUNCTION: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates. {ECO:0000269\|PubMed:8408018, ECO:0000269\|PubMed:8408019, ECO:0000269\|PubMed:8408021, ECO:0000269\|PubMed:8662720}.
RRID

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U-Blot® FPGS Rabbit mAb

Product details

Specifications

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U-Blot® FPGS Rabbit mAb

Product details

Specifications

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