Name: FRS2 Polyclonal Antibody
SKU: WP12372
Price: 268 USD
Availability: InStock

FRS2 Polyclonal Antibody

Ucallm_WP12372-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WP12372-100

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Product details

Background:

function:Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1., PTM:Phosphorylated on tyrosine residues upon stimulation by NGF., PTM:Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination., sequence caution:Translated as stop., similarity:Contains 1 IRS-type PTB domain., subcellular location:Cytoplasmic, membrane-bound., subunit:Part of a complex containing FRS2, GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity). Binds FGFR1, SUC1, NTRK1, NTRK2, NTRK3 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11., tissue specificity:Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.,

Specifications

Size	50μL/100μL
Target	FRS2
Reactivity	Human, Mouse
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	65kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human FRS2. AA range:162-211
Specificity	FRS2 Polyclonal Antibody detects endogenous levels of FRS2 protein.
Gene Name	FRS2
Protein Name	Fibroblast growth factor receptor substrate 2
Other Name	FRS2; / Fibroblast growth factor receptor substrate 2; / FGFR substrate 2; / FGFR-signaling adaptor SNT; / Suc1-associated neurotrophic factor target 1; / SNT-1
Species	Human
Gene ID	10818
Uniprot	Q8WU20,
Species.1	Mouse
Gene ID.1	327826
Uniprot.1	Q8C180
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Endomembrane system. Cytoplasmic, membrane-bound.
Tissue Expression	Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.
Signaling_pathway	Organismal Systems >> Nervous system >> Neurotrophin signaling pathway
Research Areas	>>Thermogenesis; / >>Neurotrophin signaling pathway; / >>Proteoglycans in cancer
Function	Function:Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.,PTM:Phosphorylated on tyrosine residues upon stimulation by NGF.,PTM:Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination.,sequence Caution:Translated as stop.,similarity:Contains 1 IRS-type PTB domain.,subcellular location:Cytoplasmic, membrane-bound.,subunit:Part of a complex containing FRS2, GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity). Binds FGFR1, SUC1, NTRK1, NTRK2, NTRK3 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11.,tissue specificity:Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.,