Price range: $268.00 through $328.00
Background:
The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010],
| Size | 50μL/100μL |
| Target | FSHR |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 70kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC: 100-300; WB 1:500-1:2000; ELISA 1:5000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human FSHR. AA range:211-260 |
| Specificity | FSHR Polyclonal Antibody detects endogenous levels of FSHR protein. |
| Gene Name | FSHR |
| Protein Name | Follicle-stimulating hormone receptor |
| Other Name | FSHR; / LGR1; / Follicle-stimulating hormone receptor; / FSH-R; / Follitropin receptor |
| Species | Human |
| Gene ID | 2492 |
| Uniprot | P23945, |
| Species.1 | Mouse |
| Gene ID.1 | 14309 |
| Uniprot.1 | P35378, |
| Species.2 | Rat |
| Gene ID.2 | 25449 |
| Uniprot.2 | P20395 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . |
| Tissue Expression | Sertoli cells and ovarian granulosa cells. |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> cAMP signaling pathway |
| Research Areas | >>cAMP signaling pathway; / >>Neuroactive ligand-receptor interaction; / >>Ovarian steroidogenesis |
| Function | Disease:Defects in FSHR are a cause of ovarian dysgenesis 1 (ODG1) [MIM:233300]; also known as premature ovarian failure or gonadal dysgenesis XX type or XX gonadal dysgenesis (XXGD) or hereditary hypergonadotropic ovarian failure or hypergonadotropic ovarian dysgenesis with normal karyotype. ODG1 is an autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).,Disease:Defects in FSHR are a cause of ovarian hyperstimulation syndrome (OHSS) [MIM:608115]. OHSS is a disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis.,Function:Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.,online information:Glycoprotein-hormone Receptors Information System,online information:The Singapore human mutation and polymorphism database,PTM:N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone.,similarity:Belongs to the G-protein coupled receptor 1 family.,similarity:Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.,similarity:Contains 10 LRR (leucine-rich) repeats.,tissue specificity:Sertoli cells and ovarian granulosa cells., |
