Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Dec 2009],
| Size | 50μL/100μL |
| Target | FTCD |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 60kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human FTCD AA range: 157-207 |
| Specificity | This antibody detects endogenous levels of FTCD at Human/Mouse/Rat |
| Gene Name | FTCD |
| Protein Name | FTCD |
| Other Name | |
| Species | Human |
| Gene ID | 10841 |
| Uniprot | O95954, |
| Species.1 | Mouse |
| Gene ID.1 | 14317 |
| Uniprot.1 | Q91XD4, |
| Species.2 | Rat |
| Gene ID.2 | 89833 |
| Uniprot.2 | O88618 |
| Cellular Localization | Cytoplasm, cytosol . Golgi apparatus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . More abundantly located around the mother centriole. . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | >>Histidine metabolism; / >>One carbon pool by folate; / >>Metabolic pathways |
| Function | Catalytic activity:5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate.,Catalytic activity:5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH(3).,Catalytic activity:5-formyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formyl-L-glutamate.,cofactor:Pyridoxal phosphate.,Disease:Defects in FTCD are the cause of glutamate formiminotransferase deficiency [MIM:229100]; also known as formiminoglutamicaciduria (FIGLU-uria). It is an autosomal recessive disorder. Features of a severe phenotype, include elevated levels of formiminoglutamate (FIGLU) in the urine in response to histidine administration, megaloblastic anemia, and mental retardation. Features of a mild phenotype include high urinary excretion of FIGLU in the absence of histidine administration, mild developmental delay, and no hematological abnormalities.,Function:Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.,pathway:Amino-acid degradation; L-histidine degradation into L-glutamate; L-glutamate from N-formimidoyl-L-glutamate (transferase route): step 1/1.,pathway:One-carbon metabolism; tetrahydrofolate pathway.,similarity:In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family.,similarity:In the N-terminal section; belongs to the formiminotransferase family.,subunit:Homooctamer, including four polyglutamate binding sites. The subunits are arranged as a tetramer of dimers, and form a planar ring-shaped structure., |
