Price range: $268.00 through $328.00
Background:
This gene encodes a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the synthesis of soluble A and B antigens. This is one of two genes encoding the galactoside 2-L-fucosyltransferase enzyme. Mutations in this gene are a cause of the H-Bombay blood group. [provided by RefSeq, Aug 2016],
| Size | 50μL/100μL |
| Target | FUT1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 40kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human FUT1 AA range: 150-200 |
| Specificity | This antibody detects endogenous levels of FUT1 at Human/Mouse/Rat |
| Gene Name | FUT1 H HSC |
| Protein Name | FUT1 |
| Other Name | |
| Species | Human |
| Gene ID | 2523 |
| Uniprot | P19526, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | O09160, |
| Species.2 | Rat |
| Gene ID.2 | 81919 |
| Uniprot.2 | Q10980 |
| Cellular Localization | Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein . Membrane-bound form in trans cisternae of Golgi. . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | >>Glycosphingolipid biosynthesis - lacto and neolacto series; / >>Glycosphingolipid biosynthesis - globo and isoglobo series; / >>Metabolic pathways |
| Function | Catalytic activity:GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(11)-ceramide = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(11)-ceramide.,Function:Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values.,miscellaneous:There are two genes (FUT1 and FUT2) which encode galactoside 2-L-fucosyltransferase. They are expressed in a tissue-specific manner with expression restricted to cells of mesodermal or endodermal origin respectively.,online information:Blood group antigen gene mutation database,online information:Fucosyltransferase 1,online information:GlycoGene database,pathway:Protein modification; protein glycosylation.,polymorphism:Nonfunctional mutant of FUT1 are the cause of the H-Bombay blood group.,similarity:Belongs to the glycosyltransferase 11 family.,subcellular location:Membrane-bound form in trans cisternae of Golgi., |
