U-Blot® P2Y12 Rabbit mAb
Ucallm_WR5120-50
Price range: $268.00 through $328.00
Product details
Background:The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013],
Specifications
| Size | 50μL/100μL |
| Target | P2Y12 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IF, IP, ELISA, IHC |
| MW(Calculated) | 39kD |
| MW(Observed) | 55kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; IHC 1:1000-1:5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1329R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | P2RY12 HORK3 |
| Protein Name | P2Y purinoceptor 12 (P2Y12) (ADP-glucose receptor) (ADPG-R) (P2T(AC)) (P2Y(AC)) (P2Y(cyc)) (P2Y12 platelet ADP receptor) (P2Y(ADP)) (SP1999) |
| Other Name | |
| Species | Human |
| Gene ID | 64805 |
| Uniprot | Q9H244, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9CPV9, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q9EPX4 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . |
| Tissue Expression | Highly expressed in the platelets, lower levels in the brain. Lowest levels in the lung, appendix, pituitary and adrenal gland. Expressed in the spinal cord and in the fetal brain. |
| Signaling_pathway | Organismal Systems >> Immune system >> Platelet activation |
| Research Areas | >>Platelet activation |
| Function | Disease:Defects in P2RY12 are a cause of bleeding disorder [MIM:609821].,Function:Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelets aggregation.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Highly expressed in the platelets, lower levels in the brain. Lowest levels in the lung, appendix, pituitary and adrenal gland. Expressed in the spinal cord and in the fetal brain., |
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