Gab 2 Polyclonal Antibody
Ucallm_WP12391-50
Price range: $268.00 through $328.00
Product details
Background:
GRB2 associated binding protein 2(GAB2) Homo sapiens This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009],
Specifications
| Size | 50μL/100μL |
| Target | Gab2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 74kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Gab2. AA range:589-638 |
| Specificity | Gab 2 Polyclonal Antibody detects endogenous levels of Gab 2 protein. |
| Gene Name | GAB2 |
| Protein Name | GRB2-associated-binding protein 2 |
| Other Name | GAB2; / KIAA0571; / GRB2-associated-binding protein 2; / GRB2-associated binder 2; / Growth factor receptor bound protein 2-associated protein 2; / pp100 |
| Species | Human |
| Gene ID | 9846 |
| Uniprot | Q9UQC2, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9Z1S8, |
| Species.2 | Rat |
| Gene ID.2 | 84477 |
| Uniprot.2 | Q9EQH1 |
| Cellular Localization | Cytoplasm . Cell membrane . |
| Tissue Expression | Brain,Clones donated by Kazusa DNA Research Inst., |
| Signaling_pathway | Organismal Systems >> Immune system >> Fc epsilon RI signaling pathway;Organismal Systems >> Immune system >> Fc gamma R-mediated phagocytosis;Organismal Systems >> Development and regeneration >> Osteoclast differentiation;Human Diseases >> Cancer: specific types >> Chronic myeloid leukemia;Environmental Information Processing >> Signal transduction >> Ras signaling pathway;Environmental Information Processing >> Signal transduction >> Phospholipase D signaling pathway;Environmental Information Processing >> Signal transduction >> Sphingolipid signaling pathway |
| Research Areas | >>Ras signaling pathway; / >>Sphingolipid signaling pathway; / >>Phospholipase D signaling pathway; / >>Osteoclast differentiation; / >>Fc epsilon RI signaling pathway; / >>Fc gamma R-mediated phagocytosis; / >>Chronic myeloid leukemia |
| Function | PTM:Dephosphorylated by PTPN11.,PTM:Phosphorylated on tyrosine residue(s) by the thrombopoietin receptor (TPOR), stem cell factor receptor (SCFR), and T-cell and B-cell antigen receptors, gp130, IL-2R and IL-3R.,similarity:Belongs to the GAB family.,similarity:Contains 1 PH domain.,subunit:Interacts with GRB2, PI-3 kinase and with other SH2-containing proteins., |
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