GABAA Rα4 Polyclonal Antibody
Ucallm_WP12395-50
Price range: $268.00 through $328.00
Product details
Background:
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011],
Specifications
| Size | 50μL/100μL |
| Target | GABRA4 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 60kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GABRA4. AA range:81-130 |
| Specificity | GABAA Rα4 Polyclonal Antibody detects endogenous levels of GABAA Rα4 protein. |
| Gene Name | GABRA4 |
| Protein Name | Gamma-aminobutyric acid receptor subunit alpha-4 |
| Other Name | GABRA4; / Gamma-aminobutyric acid receptor subunit alpha-4; / GABA; / A; / receptor subunit alpha-4 |
| Species | Human |
| Gene ID | 2557 |
| Uniprot | P48169, |
| Species.1 | Mouse |
| Gene ID.1 | 14397 |
| Uniprot.1 | Q9D6F4, |
| Species.2 | Rat |
| Gene ID.2 | 140675 |
| Uniprot.2 | P28471 |
| Cellular Localization | Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. |
| Tissue Expression | Brain,Brain cortex, |
| Signaling_pathway | |
| Research Areas | >>Neuroactive ligand-receptor interaction; / >>Retrograde endocannabinoid signaling; / >>GABAergic synapse; / >>Taste transduction; / >>Morphine addiction; / >>Nicotine addiction |
| Function | Function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,induction:The alpha4 beta2 gamma 2L receptor is not repressed by diazepam.,online information:Forbidden fruit - Issue 56 of March 2005,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho., |
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