Gads Polyclonal Antibody
Ucallm_WP12405-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014],
Specifications
| Size | 50μL/100μL |
| Target | GRAP2 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 38kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GRAP2. AA range:121-170 |
| Specificity | Gads Polyclonal Antibody detects endogenous levels of Gads protein. |
| Gene Name | GRAP2 |
| Protein Name | GRB2-related adapter protein 2 |
| Other Name | GRAP2; / GADS; / GRB2L; / GRID; / GRB2-related adapter protein 2; / Adapter protein GRID; / GRB-2-like protein; / GRB2L; / GRBLG; / GRBX; / Grf40 adapter protein; / Grf-40; / Growth factor receptor-binding protein; / Hematopoietic cell-associated adapter protein Grp |
| Species | Human |
| Gene ID | 9402 |
| Uniprot | O75791, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | O89100 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Cytoplasm . Endosome . |
| Tissue Expression | Blood,Lung,Platelet,Spleen,T-cell,Thymus, |
| Signaling_pathway | Organismal Systems >> Immune system >> T cell receptor signaling pathway |
| Research Areas | >>T cell receptor signaling pathway |
| Function | Function:Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.,similarity:Belongs to the GRB2/sem-5/DRK family.,similarity:Contains 1 SH2 domain.,similarity:Contains 2 SH3 domains.,subunit:Interacts with phosphorylated LIME1 upon TCR activation (By similarity). Interacts with phosphorylated LAT and LAX1 upon TCR activation. Interacts with SHB., |
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