Galectin 3 [ABT-GAL3] mouse mAb
Ucallm_WM1674-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2014],
Specifications
| Size | 50μL/100μL |
| Target | Galectin-3 |
| Reactivity | Human |
| Applications | IHC, ELISA |
| MW(Calculated) | 26kD |
| MW(Observed) | 33kD |
| Host Species | Mouse |
| Isotype | IgG2b,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:50-100; ELISA 1:500-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMM-GAL3 |
| Immunogen | Synthesized peptide derived from human Galectin-3 AA range: 150-250 |
| Specificity | The antibody can specifically recognize human Galectin-3 protein. |
| Gene Name | LGALS3 MAC2 |
| Protein Name | Galectin 3 |
| Other Name | Galectin-3; / Gal-3; / 35 kDa lectin; / Carbohydrate-binding protein 35; / CBP 35; / Galactose-specific lectin 3; / Galactoside-binding protein; / GALBP; / IgE-binding protein; / L-31; / Laminin-binding protein; / Lectin L-29; / Mac-2 antigen |
| Species | Human |
| Gene ID | 3958 |
| Uniprot | P17931 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasmic, Nuclear |
| Tissue Expression | A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis.,online information:Galectin-3,similarity:Contains 1 galectin domain.,subcellular location:Cytoplasmic in adenomas and carcinomas. May be secreted by a non-classical secretory pathway and associate with the cell surface.,subunit:Probably forms homo- or heterodimers. Interacts with DMBT1 (By similarity). Forms a complex with the ITGA3, ITGB1 and CSPG4. Interacts with LGALS3BP, LYPD3, CYHR1 and UACA.,tissue specificity:A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages., |
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