GALT2 rabbit pAb
Ucallm_WP3601-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the glycosyltransferase 2 protein family. Members of this family initiate mucin-type O-glycoslation of peptides in the Golgi apparatus. The encoded protein may be involved in O-linked glycosylation of the immunoglobulin A1 hinge region. This gene may influence triglyceride levels, and may be involved Type 2 diabetes, as well as several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],
Specifications
| Size | 50μL/100μL |
| Target | GALT2 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 65kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human GALT2 AA range: 30-80 |
| Specificity | This antibody detects endogenous levels of GALT2 at Human/Mouse |
| Gene Name | GALNT2 |
| Protein Name | GALT2 |
| Other Name | Polypeptide N-acetylgalactosaminyltransferase 2; / Polypeptide GalNAc transferase 2; / GalNAc-T2; / pp-GaNTase 2; / Protein-UDP acetylgalactosaminyltransferase 2; / UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2; / [Cleaved into: Polypeptide N-acetylgalactosaminyltransferase 2 soluble form] |
| Species | Human |
| Gene ID | 2590 |
| Uniprot | Q10471, |
| Species.1 | Mouse |
| Gene ID.1 | 108148 |
| Uniprot.1 | Q6PB93 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein . Secreted . Resides preferentially in the trans and medial parts of the Golgi stack. A secreted form also exists. |
| Tissue Expression | Widely expressed. |
| Signaling_pathway | |
| Research Areas | >>Mucin type O-glycan biosynthesis; / >>Other types of O-glycan biosynthesis; / >>Metabolic pathways |
| Function | Catalytic activity:UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide.,cofactor:Calcium.,cofactor:Manganese.,Domain:The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.,Domain:There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.,Function:Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region.,online information:GlycoGene database,online information:Polypeptide N-acetylgalactosaminyltransferase 2,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.,similarity:Contains 1 ricin B-type lectin domain.,subcellular location:Resides preferentially in the trans and medial parts of the Golgi stack. A secreted form also exists.,tissue specificity:Widely expressed., |
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