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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/Gas6 Polyclonal Antibody
SKU: WP12425 Categories: ,

Gas6 Polyclonal Antibody

Ucallm_WP12425-50

Price range: $268.00 through $328.00

SKU: WP12425-100
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Product details

Background:

This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014],

Specifications

Size50μL/100μL
TargetGAS6
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)75kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human GAS6. AA range:291-340
SpecificityGAS6 Polyclonal Antibody detects endogenous levels of GAS6 protein.
Gene NameGAS6
Protein NameGrowth arrest-specific protein 6
Other NameGAS6; / AXLLG; / Growth arrest-specific protein 6; / GAS-6; / AXL receptor tyrosine kinase ligand
SpeciesHuman
Gene ID2621
UniprotQ14393,
Species.1Mouse
Gene ID.1
Uniprot.1Q61592
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationSecreted .
Tissue ExpressionPlasma. Isoform 1 and isoform 2 are widely expressed, isoform 1 being expressed at higher levels than isoform 2 in most tissues. Isoform 2 is the predominant form in spleen.
Signaling_pathway
Research Areas>>EGFR tyrosine kinase inhibitor resistance
FunctionFunction:Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. Plays a role in thrombosis by amplifying platelet aggregation and secretion in response to known agonists.,PTM:Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.,PTM:Isoform 1 is proteolytically processed after secretion to yield a N-terminal 36 kDa protein and a C-terminal 50 kDa protein including the laminin G-like domains which activates AXL.,similarity:Contains 1 Gla (gamma-carboxy-glutamate) domain.,similarity:Contains 2 laminin G-like domains.,similarity:Contains 4 EGF-like domains.,subunit:Heterodimer and heterotetramer with AXL.,tissue specificity:Plasma. Isoform 1 and isoform 2 are widely expressed. Isoform 1 is the predominant form in spleen.,
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