Price range: $268.00 through $328.00
Background:
Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17. [provided by RefSeq, Jul 2008],
| Target | Gastrin |
| Reactivity | Human |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 11kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | IgG2b,Kappa |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | IHC 1:200-400; IF 1:50-200; ELISA 1:500-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Source | |
| Purification | The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | ABT174 |
| Immunogen | Synthesized peptide derived from human Gastrin AA range: 50-101 |
| Sequence | |
| Specificity | The antibody can specifically recognize human Gastrin protein. |
| Gene Name | GAST GAS |
| Protein Name | Gastrin [Cleaved into: Gastrin-71 (Gastrin component I); Gastrin-52 (G52); Big gastrin (Gastrin component II) (Gastrin-34) (G34); Gastrin (Gastrin component III) (Gastrin-17) (G17); Gastrin-14 (G14); Gastrin-6 (G6)] |
| Other Name | Gastrin [Cleaved into: Gastrin-71; / Gastrin component I; / Gastrin-52; / G52; / Big gastrin; / Gastrin component II; / Gastrin-34; / G34; / Gastrin; / Gastrin component III; / Gastrin-17; / G17; / Gastrin-14; / G14; / Gastrin-6; / G6; / ] |
| Species | Human |
| Gene ID-1 | 2520 |
| Uniprot | P01350 |
| Species.1 | |
| Gene ID-2 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID-3 | |
| Uniprot.2 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17. [provided by RefSeq, Jul 2008], |
| Cellular Localization | Cytoplasmic |
| Tissue Expression | Cytoplasmic |
| Signaling_pathway | |
| Research Areas | >>Gastric acid secretion |
| Function | Function:Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.,online information:Gastrin entry,PTM:Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific.,PTM:Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71.,similarity:Belongs to the gastrin/cholecystokinin family., |
| RRID |
