Product details
Background:
Guanylate-binding proteins, such as GBP4, are induced by interferon and hydrolyze GTP to both GDP and GMP (Vestal, 2005 [PubMed 16108726]).[supplied by OMIM, Dec 2008],
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GBP4 Polyclonal Antibody
Ucallm_WP12438-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | GBP4 |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 73kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GBP4. AA range:551-600 |
| Specificity | GBP4 Polyclonal Antibody detects endogenous levels of GBP4 protein. |
| Gene Name | GBP4 |
| Protein Name | Guanylate-binding protein 4 |
| Other Name | GBP4; / Guanylate-binding protein 4; / GTP-binding protein 4; / GBP-4; / Guanine nucleotide-binding protein 4 |
| Species | Human |
| Gene ID | 115361 |
| Uniprot | Q96PP9, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q61107 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Nucleus . Cytoplasm, perinuclear region . Golgi apparatus membrane . Heterodimers with GBP1, GBP2 and GBP5 localize in the compartment of the prenylated GBPs: with GBP1 in a vesicle-like compartment, with GBP2, around the nucleus and with GBP-5, at the Golgi apparatus. . |
| Tissue Expression | Brain,Epithelium,Placenta,Spinal cord,Spleen,Testis, |
| Signaling_pathway | Organismal Systems >> Immune system >> NOD-like receptor signaling pathway |
| Research Areas | >>NOD-like receptor signaling pathway |
| Function | Function:Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation.,similarity:Belongs to the GBP family., |
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