GBRA5 rabbit pAb
Ucallm_WP4222-50
Price range: $268.00 through $328.00
Product details
Background:
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | GBRA5 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 51kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human GBRA5 AA range: 234-284 |
| Specificity | This antibody detects endogenous levels of GBRA5 at Human/Mouse/Rat |
| Gene Name | GABRA5 |
| Protein Name | GBRA5 |
| Other Name | |
| Species | Human |
| Gene ID | 2558 |
| Uniprot | P31644, |
| Species.1 | Mouse |
| Gene ID.1 | 110886 |
| Uniprot.1 | Q8BHJ7, |
| Species.2 | Rat |
| Gene ID.2 | 29707 |
| Uniprot.2 | P19969 |
| Cellular Localization | Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | >>Neuroactive ligand-receptor interaction; / >>Retrograde endocannabinoid signaling; / >>GABAergic synapse; / >>Taste transduction; / >>Morphine addiction; / >>Nicotine addiction |
| Function | Function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,online information:Forbidden fruit - Issue 56 of March 2005,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho., |
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