SKU: WP16794 Categories: ,

GDF11 rabbit pAb

Price range: $268.00 through $328.00

SKU: WP16794-100
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Product details

Background:

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and other organ systems, and may regulate aging. [provided by RefSeq, Aug 2016],

Specifications

Size50μL/100μL
TargetGDF11
ReactivityHuman, Mouse, Rat
ApplicationsWB
MW(Calculated)45kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human GDF11 AA range: 217-267
SpecificityThis antibody detects endogenous levels of GDF11 at Human/Mouse/Rat
Gene NameGDF11 BMP11
Protein NameGDF11
Other Name
SpeciesHuman
Gene ID10220
UniprotO95390,
Species.1Mouse
Gene ID.114561
Uniprot.1Q9Z1W4,
Species.2Rat
Gene ID.2
Uniprot.2Q9Z217
Cellular LocalizationSecreted .
Tissue ExpressionIn the embryo, strong expression is seen in the palatal epithelia, including the medial edge epithelial and midline epithelial seam of the palatal shelves. Less pronounced expression is also seen throughout the palatal shelf and tongue mesenchyme.
Signaling_pathwayEnvironmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Research Areas>>Cytokine-cytokine receptor interaction
FunctionFunction:Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern.,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,
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