Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | GFRα-4 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 30kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GFRA4. AA range:141-190 |
| Specificity | GFRα-4 Polyclonal Antibody detects endogenous levels of GFRα-4 protein. |
| Gene Name | GFRA4 |
| Protein Name | GDNF family receptor alpha-4 |
| Other Name | GFRA4; / GDNF family receptor alpha-4; / GDNF receptor alpha-4; / GDNFR-alpha-4; / GFR-alpha-4; / Persephin receptor |
| Species | Human |
| Gene ID | 64096 |
| Uniprot | Q9GZZ7, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9JJT2 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | [Isoform GFRalpha4a]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform GFRalpha4b]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform GFRalpha4c]: Secreted. |
| Tissue Expression | Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands. |
| Signaling_pathway | |
| Research Areas | |
| Function | Alternative products:Additional isoforms seem to exist,Function:Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.,similarity:Belongs to the GDNFR family.,tissue specificity:Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands., |
