Price range: $268.00 through $328.00
Background:
GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | GFRP |
| Reactivity | Human, Rat |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 10kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GCHFR. AA range:31-80 |
| Specificity | GFRP Polyclonal Antibody detects endogenous levels of GFRP protein. |
| Gene Name | GCHFR |
| Protein Name | GTP cyclohydrolase 1 feedback regulatory protein |
| Other Name | GCHFR; / GFRP; / GTP cyclohydrolase 1 feedback regulatory protein; / GFRP; / GTP cyclohydrolase I feedback regulatory protein; / p35 |
| Species | Human |
| Gene ID | 2644 |
| Uniprot | P30047, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P99025, |
| Species.2 | Rat |
| Gene ID.2 | 171128 |
| Uniprot.2 | P70552 |
| Cellular Localization | Nucleus . Nucleus membrane . Cytoplasm, cytosol . |
| Tissue Expression | In epidermis, expressed predominantly in basal undifferentiated keratinocytes and in some but not all melanocytes (at protein level). |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine.,similarity:Belongs to the GFRP family.,subunit:Homopentamer. Forms a complex with GCH1 where a GCH1 homodecamer is sandwiched by two GFRP homopentamers (By similarity). Interacts with GCH1.,tissue specificity:In epidermis, expressed predominantly in basal undifferentiated keratinocytes and in some but not all melanocytes (at protein level)., |
