Price range: $268.00 through $328.00
Background:
GGT2 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008],
| Target | GGT2 |
| Reactivity | Human |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 60kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human GGT2 AA range: 89-139 |
| Sequence | |
| Specificity | This antibody detects endogenous levels of GGT2 at Human |
| Gene Name | GGT2 |
| Protein Name | GGT2 |
| Other Name | Gamma-glutamyltranspeptidase 2; / GGT 2; / Gamma-glutamyltransferase 2; / Glutathione hydrolase 2; / [Cleaved into: Gamma-glutamyltranspeptidase 2 heavy chain; / Gamma-glutamyltranspeptidase 2 light chain] |
| Species | Human |
| Gene ID-1 | |
| Uniprot | P36268 |
| Species.1 | |
| Gene ID-2 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID-3 | |
| Uniprot.2 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | GGT2 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008], |
| Cellular Localization | Cytoplasm, perinuclear region . Endoplasmic reticulum . Co-localizes with calnexin in the endoplasmic reticulum. |
| Tissue Expression | Highly expressed in fetal and adult kidney and liver. |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid.,Disease:Defects in GGT1 are a cause of glutathionuria [MIM:231950]; also known as gamma-glutamyltranspeptidase deficiency. It is an autosomal recessive disease.,Function:Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive.,Function:Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors.,miscellaneous:Corresponds to the light chain of other gamma-glutamyltransferase family members.,miscellaneous:Cys-454 was thought to bind the gamma-glutamyl moiety, but mutagenesis of this residue had no effect on activity.,online information:Gamma-glutamyl transpeptidase entry,pathway:Sulfur metabolism; glutathione metabolism.,PTM:N-glycosylated on both chains. Contains hexoses, hexosamines and sialic acid residues. It is not known if the sialic acid residues are present on N-linked or on O-linked glycans.,similarity:Belongs to the gamma-glutamyltransferase family.,subunit:Heterodimer composed of the light and heavy chains. The active site is located in the light chain.,tissue specificity:Detected in fetal and adult kidney and liver, adult pancreas, stomach, intestine, placenta and lung. Isoform 3 is lung-specific. There are several other tissue-specific forms that arise from alternative promoter usage but that produce the same protein.,tissue specificity:Highly expressed in fetal and adult kidney and liver., |
| RRID |
