Glial Fibrillary Acidic Protein [GFAP] [ABT176] mouse mAb
Ucallm_WM1424-50
Price range: $268.00 through $328.00
Product details
Background:
GFAP is an intermediate filament protein with a molecular weight of 51 kDa, which participates in the formation of cytoskeleton and maintains its tension strength. GFAP is mainly distributed in astrocytes and ependymal cells of the central nervous system, Schwann cells and satellite cells of intestinal ganglion of the peripheral nervous system, myoepithelial cells and chondroblasts. It is mainly used for the diagnosis and differential diagnosis of astrocytoma, including astrocytoma, astroblastoma, mixed glioma, pleomorphic glioblastoma and non astrocytoma, including a few gliomas, most ependymomas and other central nervous system tumors.
Specifications
| Size | 50μL/100μL |
| Target | Glial Fibrillary Acidic Protein |
| Reactivity | Human, Rat, Monkey, Bovine |
| Applications | IHC, WB, IF, ELISA |
| MW(Calculated) | 49kD |
| MW(Observed) | 50kD |
| Host Species | Mouse |
| Isotype | IgG2b,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMM176 |
| Immunogen | Synthesized peptide derived from human Glial Fibrillary Acidic Protein AA range: 300-432 |
| Specificity | The antibody can specifically recognize human GFAP protein. |
| Gene Name | GFAP |
| Protein Name | wu:fb34h11; ALXDRD; cb345; etID36982.3; FLJ42474; FLJ45472; GFAP; GFAP_HUMAN; gfapl; Glial fibrillary acidic protein; Intermediate filament protein; wu:fk42c12; xx:af506734; zgc:110485 |
| Other Name | wu:fb34h11; / ALXDRD; / cb345; / etID36982.3; / FLJ42474; / FLJ45472; / GFAP; / GFAP_HUMAN; / gfapl; / Glial fibrillary acidic protein; / Intermediate filament protein; / wu:fk42c12; / xx:af506734; / zgc:110485 |
| Species | Human |
| Gene ID | 2670 |
| Uniprot | P14136, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P03995, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P47819 |
| Cellular Localization | Cytoplasmic |
| Tissue Expression | Brain/ Colon |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway |
| Research Areas | >>JAK-STAT signaling pathway |
| Function | Alternative products:Isoforms differ in the C-terminal region which is encoded by alternative exons,Disease:Defects in GFAP are a cause of Alexander disease (ALEXD) [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.,Function:GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.,online information:GFAP entry,similarity:Belongs to the intermediate filament family.,subcellular location:Associated with intermediate filaments.,subunit:Interacts with SYNM (By similarity). Isoform 3 interacts with PSEN1 (via N-terminus).,tissue specificity:Expressed in cells lacking fibronectin., |
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