Price range: $268.00 through $328.00
Background:
mitogen-activated protein kinase kinase kinase kinase 3(MAP4K3) Homo sapiens This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012],
| Size | 50μL/100μL |
| Target | GLK |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 101kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MAP4K3. AA range:10-59 |
| Specificity | GLK Polyclonal Antibody detects endogenous levels of GLK protein. |
| Gene Name | MAP4K3 |
| Protein Name | Mitogen-activated protein kinase kinase kinase kinase 3 |
| Other Name | MAP4K3; / RAB8IPL1; / Mitogen-activated protein kinase kinase kinase kinase 3; / Germinal center kinase-related protein kinase; / GLK; / MAPK/ERK kinase kinase kinase 3; / MEK kinase kinase 3; / MEKKK 3 |
| Species | Human |
| Gene ID | 8491 |
| Uniprot | Q8IVH8, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q99JP0, |
| Species.2 | Rat |
| Gene ID.2 | 170920 |
| Uniprot.2 | Q924I2 |
| Cellular Localization | intracellular,cytoplasm, |
| Tissue Expression | Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver. |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> MAPK signaling pathway |
| Research Areas | >>MAPK signaling pathway |
| Function | Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,Function:May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 CNH domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with SH3GL2. Interaction appears to regulate MAP4K3-mediated JNK activation.,tissue specificity:Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver., |
