Product details
Background:
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GLRA1 rabbit pAb
Ucallm_WP6436-50
Price range: $268.00 through $328.00
Specifications
| Target | GLRA1 |
| Reactivity | Human, Rat |
| Applications | WB |
| MW(Calculated) | 50kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human GLRA1 |
| Sequence | |
| Specificity | This antibody detects endogenous levels of GLRA1 at Human,Rat |
| Gene Name | GLRA1 |
| Protein Name | Glycine receptor subunit alpha-1 (Glycine receptor 48 kDa subunit) (Glycine receptor strychnine-binding subunit) |
| Other Name | |
| Species | Human |
| Gene ID-1 | 2741 |
| Uniprot | P23415, |
| Species.1 | Mouse |
| Gene ID-2 | |
| Uniprot.1 | Q64018, |
| Species.2 | Rat |
| Gene ID-3 | 25674 |
| Uniprot.2 | P07727 |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | |
| Cellular Localization | Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein . Cell junction, synapse . Perikaryon . Cell projection, dendrite . Cell membrane; Multi-pass membrane protein . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Glycine receptors are ligand-gated chloride channels . Channel opening is triggered by extracellular glycine . Channel opening is also triggered by taurine and beta-alanine . Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization . Plays an important role in the down-regulation of neuronal excitability . Contributes to the generation of inhibitory postsynaptic currents . Channel activity is potentiated by ethanol . Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity). |
| RRID |
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