Product details
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GLRA3 rabbit pAb
Ucallm_WP6864-50
Price range: $268.00 through $328.00
Specifications
| Target | GLRA3 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 51kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human GLRA3 |
| Sequence | |
| Specificity | This antibody detects endogenous levels of GLRA3 at Human, Mouse,Rat |
| Gene Name | GLRA3 |
| Protein Name | Glycine receptor subunit alpha-3 |
| Other Name | |
| Species | Human |
| Gene ID-1 | 8001 |
| Uniprot | O75311, |
| Species.1 | Mouse |
| Gene ID-2 | 110304 |
| Uniprot.1 | Q91XP5, |
| Species.2 | Rat |
| Gene ID-3 | |
| Uniprot.2 | P24524 |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | |
| Cellular Localization | Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein . Perikaryon . Cell projection, dendrite . Cell junction, synapse . Cell membrane; Multi-pass membrane protein . Partially colocalizes with GPHN that is known to mediate receptor clustering at postsynaptic membranes. . |
| Tissue Expression | Widely distributed throughout the central nervous system. |
| Signaling_pathway | |
| Research Areas | |
| Function | Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine . Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability (By similarity). Contributes to the generation of inhibitory postsynaptic currents (By similarity). Contributes to increased pain perception in response to increased prostaglandin E2 levels (By similarity). Plays a role in cellular responses to ethanol (By similarity). |
| RRID |
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