Product details
Background:
GLS2 rabbit pAb
Ucallm_WP9012-50
Price range: $268.00 through $328.00
Specifications
| Target | GLS2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 66kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human GLS2 |
| Sequence | |
| Specificity | This antibody detects endogenous levels of GLS2 at Human, Mouse,Rat |
| Gene Name | GLS2 GA |
| Protein Name | Glutaminase liver isoform, mitochondrial (GLS) (L-glutaminase) (L-glutamine amidohydrolase) |
| Other Name | |
| Species | Human |
| Gene ID-1 | 27165 |
| Uniprot | Q9UI32, |
| Species.1 | Mouse |
| Gene ID-2 | 216456 |
| Uniprot.1 | Q571F8, |
| Species.2 | Rat |
| Gene ID-3 | 192268 |
| Uniprot.2 | P28492 |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | |
| Cellular Localization | Mitochondrion . |
| Tissue Expression | Highly expressed in liver. Expressed in brain and pancreas. Not observed in heart, placenta, lung, skeletal muscle and kidney. Expression is significantly reduced in hepatocellular carcinomas. |
| Signaling_pathway | Organismal Systems >> Nervous system >> Glutamatergic synapse;Human Diseases >> Cancer: overview >> MicroRNAs in cancer;Human Diseases >> Cancer: overview >> Central carbon metabolism in cancer |
| Research Areas | |
| Function | Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation. |
| RRID |
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