Price range: $268.00 through $328.00
Background:
glucagon receptor(GCGR) Homo sapiens The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010],
| Target | Glucagon Receptor |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 54kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GLR. AA range:95-144 |
| Sequence | |
| Specificity | Glucagon Receptor Polyclonal Antibody detects endogenous levels of Glucagon Receptor protein. |
| Gene Name | GCGR |
| Protein Name | Glucagon receptor |
| Other Name | GCGR; / Glucagon receptor; / GL-R |
| Species | Human |
| Gene ID-1 | 2642 |
| Uniprot | P47871, |
| Species.1 | Mouse |
| Gene ID-2 | 14527 |
| Uniprot.1 | Q61606, |
| Species.2 | Rat |
| Gene ID-3 | 24953 |
| Uniprot.2 | P30082 |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | glucagon receptor(GCGR) Homo sapiens The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010], |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . Is rapidly internalized after ligand-binding. . |
| Tissue Expression | Liver,Placenta, |
| Signaling_pathway | Organismal Systems >> Endocrine system >> Glucagon signaling pathway |
| Research Areas | >>Neuroactive ligand-receptor interaction; / >>Glucagon signaling pathway |
| Function | Disease:It is a candidate for certain defects in non-insulin-dependent diabetes mellitus (NIDDM). The variant in position 40 (Ser) is found in some NIDDM patients, but also in nondiabetic subjects.,Function:This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.,similarity:Belongs to the G-protein coupled receptor 2 family., |
| RRID |
