Price range: $268.00 through $328.00
Background:
This locus encodes a member of the glycerate kinase type-2 family. The encoded enzyme catalyzes the phosphorylation of (R)-glycerate and may be involved in serine degradation and fructose metabolism. Decreased activity of the encoded enzyme may be associated with the disease D-glyceric aciduria. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009],
| Size | 50μL/100μL |
| Target | Glycerate Kinase |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 60kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GLCTK. AA range:101-150 |
| Specificity | Glycerate Kinase Polyclonal Antibody detects endogenous levels of Glycerate Kinase protein. |
| Gene Name | GLYCTK |
| Protein Name | Glycerate kinase |
| Other Name | GLYCTK; / HBEBP4; / LP5910; / Glycerate kinase; / HBeAg-binding protein 4 |
| Species | Human |
| Gene ID | 132158 |
| Uniprot | Q8IVS8, |
| Species.1 | Mouse |
| Gene ID.1 | 235582 |
| Uniprot.1 | Q8QZY2, |
| Species.2 | Rat |
| Gene ID.2 | 684314 |
| Uniprot.2 | Q0VGK3 |
| Cellular Localization | [Isoform 1]: Cytoplasm .; [Isoform 2]: Cytoplasm. Mitochondrion . |
| Tissue Expression | Widely expressed. |
| Signaling_pathway | |
| Research Areas | >>Pentose phosphate pathway; / >>Glycine, serine and threonine metabolism; / >>Glycerolipid metabolism; / >>Glyoxylate and dicarboxylate metabolism; / >>Metabolic pathways; / >>Carbon metabolism |
| Function | Catalytic activity:ATP + (R)-glycerate = ADP + 3-phospho-(R)-glycerate.,Disease:Defects in GLYCTK are the cause of D-glyceric acidemia [MIM:220120]. It is characterized by nonketotic hyperglycinemia with the excretion of D-glyceric acid in the urine and the presence of this substance in the serum.,similarity:Belongs to the glycerate kinase type-2 family.,tissue specificity:Widely expressed., |
