Price range: $268.00 through $328.00
Background:
The protein encoded by this gene catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1, 4-glycoside linkages. Mutations in this gene are associated with muscle glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009],
| Size | 50μL/100μL |
| Target | Glycogen Synthase 1 |
| Reactivity | Human |
| Applications | WB, FC, ELISA |
| MW(Calculated) | 84kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; Flow Cyt 1:200-1:400; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 15G8 |
| Immunogen | Purified recombinant fragment of human Glycogen Synthase 1 expressed in E. Coli. |
| Specificity | Glycogen Synthase 1 Monoclonal Antibody detects endogenous levels of Glycogen Synthase 1 protein. |
| Gene Name | GYS1 |
| Protein Name | Glycogen [starch] synthase muscle |
| Other Name | GYS1; / GYS; / Glycogen [starch] synthase; / muscle |
| Species | Human |
| Gene ID | 2997 |
| Uniprot | P13807, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9Z1E4 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | cytosol,membrane,inclusion body, |
| Tissue Expression | Endometrium,Heart,Kidney,Lymph,Muscle,Skin, |
| Signaling_pathway | Organismal Systems >> Endocrine system >> Insulin signaling pathway;Organismal Systems >> Endocrine system >> Glucagon signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway;Environmental Information Processing >> Signal transduction >> AMPK signaling pathway |
| Research Areas | >>Starch and sucrose metabolism; / >>Metabolic pathways; / >>PI3K-Akt signaling pathway; / >>AMPK signaling pathway; / >>Insulin signaling pathway; / >>Glucagon signaling pathway; / >>Insulin resistance; / >>Diabetic cardiomyopathy |
| Function | Catalytic activity:UDP-glucose ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1).,Disease:Defects in GYS1 are the cause of muscle glycogen storage disease type 0 (GSD0b) [MIM:611556]; also called muscle glycogen synthase deficiency. GSD0 is a metabolic disorder characterized by fasting hypoglycemia presenting in infancy or early childhood. The role of muscle glycogen is to provide critical energy during bursts of activity and sustained muscle work.,enzyme regulation:Allosteric activation by glucose-6-phosphate. Phosphorylation reduces the activity towards UDP-glucose. When in the non-phosphorylated state, glycogen synthase does not require glucose-6-phosphate as an allosteric activator; when phosphorylated it does.,Function:Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.,pathway:Glycan biosynthesis; glycogen biosynthesis.,similarity:Belongs to the glycosyltransferase 3 family., |
