Price range: $268.00 through $328.00
Background:
The protein encoded by this gene represents the alpha subunit of the Go heterotrimeric G-protein signal-transducing complex. Defects in this gene are a cause of early-onset epileptic encephalopathy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015],
| Size | 50μL/100μL |
| Target | GNAO |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 38kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | GNAO Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | GNAO1 |
| Protein Name | Guanine nucleotide-binding protein G(o) subunit alpha |
| Other Name | |
| Species | Human |
| Gene ID | 2775 |
| Uniprot | P09471, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P18872, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P59215 |
| Cellular Localization | Cell membrane . Membrane; Lipid-anchor . |
| Tissue Expression | Brain,Endometrium,Myometrium, |
| Signaling_pathway | Organismal Systems >> Endocrine system >> Estrogen signaling pathway;Organismal Systems >> Endocrine system >> Oxytocin signaling pathway;Organismal Systems >> Endocrine system >> Relaxin signaling pathway;Organismal Systems >> Nervous system >> Glutamatergic synapse;Organismal Systems >> Nervous system >> Cholinergic synapse;Organismal Systems >> Nervous system >> Dopaminergic synapse;Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway |
| Research Areas | >>Rap1 signaling pathway; / >>Circadian entrainment; / >>Retrograde endocannabinoid signaling; / >>Glutamatergic synapse; / >>Cholinergic synapse; / >>Serotonergic synapse; / >>GABAergic synapse; / >>Dopaminergic synapse; / >>Long-term depression; / >>Estrogen signaling pathway; / >>Melanogenesis; / >>Oxytocin signaling pathway; / >>Relaxin signaling pathway; / >>Morphine addiction; / >>Alcoholism; / >>Chagas disease; / >>Toxoplasmosis; / >>Human cytomegalovirus infection; / >>Human immunodeficiency virus 1 infection |
| Function | Function:Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear.,similarity:Belongs to the G-alpha family. G(i/o/t/z) subfamily.,subunit:G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site., |
