Price range: $268.00 through $328.00
Background:
glycogen synthase kinase 3 alpha(GSK3A) Homo sapiens This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011],
| Size | 50μL/100μL |
| Target | GSK3α |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, IP, ELISA |
| MW(Calculated) | |
| MW(Observed) | 51kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IP 2-5 ug/mg lysate; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GSK3A. AA range:10-59 |
| Specificity | GSK3α Polyclonal Antibody detects endogenous levels of GSK3α protein. |
| Gene Name | GSK3A |
| Protein Name | Glycogen synthase kinase-3 alpha |
| Other Name | GSK3A; / Glycogen synthase kinase-3 alpha; / GSK-3 alpha; / Serine/threonine-protein kinase GSK3A |
| Species | Human |
| Gene ID | 2931 |
| Uniprot | P49840, |
| Species.1 | Mouse |
| Gene ID.1 | 606496 |
| Uniprot.1 | Q2NL51, |
| Species.2 | Rat |
| Gene ID.2 | 50686 |
| Uniprot.2 | P18265 |
| Cellular Localization | apical dendrite; axon; beta-catenin destruction complex; cytoplasm; cytosol; mitochondrion; neuronal cell body; nucleus; postsynapse; proximal dendrite |
| Tissue Expression | Brain,Eye,Foreskin,Lung,Pancreas,Platelet,Testis, |
| Signaling_pathway | Organismal Systems >> Immune system >> Chemokine signaling pathway;Organismal Systems >> Nervous system >> Dopaminergic synapse |
| Research Areas | >>Chemokine signaling pathway; / >>Dopaminergic synapse; / >>Non-alcoholic fatty liver disease; / >>Shigellosis |
| Function | Catalytic activity:ATP + [tau protein] = ADP + [tau protein] phosphate.,Function:Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer., |
