U-Blot® GSK3 α/β Rabbit mAb
WR4231 Western blot analysis of lysates from K562 cells, using Cdc2 Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody (WS0002) was used to detect the antibody.
Price range: $268.00 through $328.00
Product details
Background:glycogen synthase kinase 3 alpha(GSK3A) Homo sapiens This gene encodes a multifunctional Ser/Thr protein kinase that is implicated inThe control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role inThe WNT and PI3K signaling pathways, as well as regulatesThe production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011],
Specifications
| Size | 50μL/100μL |
| Target | GSK3α/β |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, IP, ELISA |
| MW(Calculated) | 51kD,47kD |
| MW(Observed) | 51kD,47kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:400-1:800; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM0413R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | GSK3A/GSK3B |
| Protein Name | Glycogen synthase kinase-3 alpha/beta |
| Other Name | GSK3A; / Glycogen synthase kinase-3 alpha; / GSK-3 alpha; / Serine/threonine-protein kinase GSK3A; / GSK3B; / Glycogen synthase kinase-3 beta; / GSK-3 beta; / Serine/threonine-protein kinase GSK3B |
| Species | Human |
| Gene ID | 2931 |
| Uniprot | P49840;P49841, |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | Rat |
| Gene ID.2 | 50686;84027 |
| Uniprot.2 | P18265;P18266 |
| Cellular Localization | Cytoplasm |
| Tissue Expression | Brain,Eye,Foreskin,Lung,Pancreas,Platelet,Testis, |
| Signaling_pathway | Organismal Systems >> Immune system >> Chemokine signaling pathway;Organismal Systems >> Nervous system >> Dopaminergic synapse |
| Research Areas | >>Chemokine signaling pathway; / >>Dopaminergic synapse; / >>Non-alcoholic fatty liver disease; / >>Shigellosis |
| Function | Catalytic activity:ATP + [tau protein] = ADP + [tau protein] phosphate.,Function:Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer., |
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